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Hes1 expression and CYLD repression are essential events downstream of Notch1 in T-cell leukemia

Notch activation is a current event in T Acute Lymphoblastic Leukemia (T-ALL) but the downstream elements that are able to support Notch-dependent leukemias are not well characterized. We have recently shown that the Notch-Hes1-CYLD-NFκB axis is crucial in the maintenance of T-ALL, but detailed eval...

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Detalhes bibliográficos
Main Authors: D’Altri, Teresa, Gonzalez, Jessica, Aifantis, Iannis, Espinosa, Lluis, Bigas, Anna
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3974883/
https://ncbi.nlm.nih.gov/pubmed/21389783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.7.15067
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