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Hes1 expression and CYLD repression are essential events downstream of Notch1 in T-cell leukemia
Notch activation is a current event in T Acute Lymphoblastic Leukemia (T-ALL) but the downstream elements that are able to support Notch-dependent leukemias are not well characterized. We have recently shown that the Notch-Hes1-CYLD-NFκB axis is crucial in the maintenance of T-ALL, but detailed eval...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Landes Bioscience
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3974883/ https://ncbi.nlm.nih.gov/pubmed/21389783 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.7.15067 |
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