Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling

Previous studies have identified Notch as a key regulator of hematopoietic stem cell (HSC) development, but the underlying downstream mechanisms remain unknown. The Notch target Hes1 is widely expressed in the aortic endothelium and hematopoietic clusters, though Hes1-deficient mice show no overt he...

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Detaylı Bibliyografya
Asıl Yazarlar: Guiu, Jordi, Shimizu, Ritsuko, D’Altri, Teresa, Fraser, Stuart T., Hatakeyama, Jun, Bresnick, Emery H., Kageyama, Ryoichiro, Dzierzak, Elaine, Yamamoto, Masayuki, Espinosa, Lluis, Bigas, Anna
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Rockefeller University Press 2013
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549704/
https://ncbi.nlm.nih.gov/pubmed/23267012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20120993
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