Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling

Previous studies have identified Notch as a key regulator of hematopoietic stem cell (HSC) development, but the underlying downstream mechanisms remain unknown. The Notch target Hes1 is widely expressed in the aortic endothelium and hematopoietic clusters, though Hes1-deficient mice show no overt he...

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Detalhes bibliográficos
Main Authors: Guiu, Jordi, Shimizu, Ritsuko, D’Altri, Teresa, Fraser, Stuart T., Hatakeyama, Jun, Bresnick, Emery H., Kageyama, Ryoichiro, Dzierzak, Elaine, Yamamoto, Masayuki, Espinosa, Lluis, Bigas, Anna
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549704/
https://ncbi.nlm.nih.gov/pubmed/23267012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20120993
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