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Ikaros Induces Quiescence and T-Cell Differentiation in a Leukemia Cell Line

Ikaros is a hematopoietic cell-specific zinc finger DNA binding protein that plays an important role in lymphocyte development. Genetic disruption of Ikaros results in T-cell transformation. Ikaros null mice develop leukemia with 100% penetrance. It has been hypothesized that Ikaros controls gene ex...

詳細記述

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書誌詳細
主要な著者: Kathrein, Katie L., Lorenz, Rachelle, Innes, Angela Minniti, Griffiths, Erin, Winandy, Susan
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2005
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC549358/
https://ncbi.nlm.nih.gov/pubmed/15713624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.5.1645-1654.2005
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