Uncoupling Anaphase-Promoting Complex/Cyclosome Activity from Spindle Assembly Checkpoint Control by Deregulating Polo-Like Kinase 1

Polo-like kinase 1 (Plk1) plays a role in numerous events in mitosis, but how the multiple functions of Plk1 are separated is poorly understood. We studied regulation of Plk1 through two putative phosphorylation residues, Ser-137 and Thr-210. Using phospho-specific antibodies, we found that Thr-210...

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Détails bibliographiques
Auteurs principaux: van de Weerdt, Barbara C. M., van Vugt, Marcel A. T. M., Lindon, Catherine, Kauw, Jos J. W., Rozendaal, Marieke J., Klompmaker, Rob, Wolthuis, Rob M. F., Medema, René H.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2005
Sujets:
Chromosome Structure and Dynamics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC549351/
https://ncbi.nlm.nih.gov/pubmed/15713655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.5.2031-2044.2005
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