Uncoupling Anaphase-Promoting Complex/Cyclosome Activity from Spindle Assembly Checkpoint Control by Deregulating Polo-Like Kinase 1

Polo-like kinase 1 (Plk1) plays a role in numerous events in mitosis, but how the multiple functions of Plk1 are separated is poorly understood. We studied regulation of Plk1 through two putative phosphorylation residues, Ser-137 and Thr-210. Using phospho-specific antibodies, we found that Thr-210...

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Hlavní autoři: van de Weerdt, Barbara C. M., van Vugt, Marcel A. T. M., Lindon, Catherine, Kauw, Jos J. W., Rozendaal, Marieke J., Klompmaker, Rob, Wolthuis, Rob M. F., Medema, René H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2005
Témata:
Chromosome Structure and Dynamics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC549351/
https://ncbi.nlm.nih.gov/pubmed/15713655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.5.2031-2044.2005
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