Uncoupling Anaphase-Promoting Complex/Cyclosome Activity from Spindle Assembly Checkpoint Control by Deregulating Polo-Like Kinase 1

Polo-like kinase 1 (Plk1) plays a role in numerous events in mitosis, but how the multiple functions of Plk1 are separated is poorly understood. We studied regulation of Plk1 through two putative phosphorylation residues, Ser-137 and Thr-210. Using phospho-specific antibodies, we found that Thr-210...

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Detalhes bibliográficos
Main Authors: van de Weerdt, Barbara C. M., van Vugt, Marcel A. T. M., Lindon, Catherine, Kauw, Jos J. W., Rozendaal, Marieke J., Klompmaker, Rob, Wolthuis, Rob M. F., Medema, René H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Chromosome Structure and Dynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC549351/
https://ncbi.nlm.nih.gov/pubmed/15713655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.5.2031-2044.2005
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