Uncoupling Anaphase-Promoting Complex/Cyclosome Activity from Spindle Assembly Checkpoint Control by Deregulating Polo-Like Kinase 1

Polo-like kinase 1 (Plk1) plays a role in numerous events in mitosis, but how the multiple functions of Plk1 are separated is poorly understood. We studied regulation of Plk1 through two putative phosphorylation residues, Ser-137 and Thr-210. Using phospho-specific antibodies, we found that Thr-210...

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Main Authors: van de Weerdt, Barbara C. M., van Vugt, Marcel A. T. M., Lindon, Catherine, Kauw, Jos J. W., Rozendaal, Marieke J., Klompmaker, Rob, Wolthuis, Rob M. F., Medema, René H.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2005
Assuntos:
Chromosome Structure and Dynamics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC549351/
https://ncbi.nlm.nih.gov/pubmed/15713655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.5.2031-2044.2005
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