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Differential Regulation of Anaphase Promoting Complex/Cyclosome Substrates by the Spindle Assembly Checkpoint in Saccharomyces cerevisiae

The anaphase promoting complex (APC) targets proteins for degradation to promote progression through the cell cycle. Here we show that Clb5, an APC(Cdc20) substrate, is degraded when the spindle checkpoint is active, while other APC(Cdc20) substrates are stabilized, suggesting that APC(Cdc20) inhibi...

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Bibliografski detalji
Glavni autori: Keyes, Brice E., Yellman, Christopher M., Burke, Daniel J.
Format: Artigo
Jezik:Inglês
Izdano: Genetics Society of America 2008
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2206106/
https://ncbi.nlm.nih.gov/pubmed/18202397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.107.083642
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