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The Canonical Notch Signaling Pathway: Structural And Biochemical Insights Into Shape, Sugar, And Force

The Notch signaling pathway relies on a proteolytic cascade to release its transcriptionally active intracellular domain, on force to unfold a protective domain and permit proteolysis, on extracellular domain glycosylation to tune the forces exerted by endocytosed ligands, and on a motley crew of nu...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Dev Cell
Main Authors: Kovall, Rhett A., Gebelein, Brian, Sprinzak, David, Kopan, Raphael
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5492985/
https://ncbi.nlm.nih.gov/pubmed/28486129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2017.04.001
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