Herpes Simplex Virus Thymidine Kinase Mutations Associated with Resistance to Acyclovir: a Site-Directed Mutagenesis Study

Mutations in the thymidine kinase (TK) gene of herpes simplex virus (HSV) may confer resistance to acyclovir (ACV). Because of the high genetic polymorphism of this gene, discriminating between mutations related to resistance and mutations related to gene polymorphism can be difficult, especially wh...

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Detalhes bibliográficos
Main Authors: Frobert, E., Ooka, T., Cortay, J. C., Lina, B., Thouvenot, D., Morfin, F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC549244/
https://ncbi.nlm.nih.gov/pubmed/15728902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.3.1055-1059.2005
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