Differential Mutation Patterns in Thymidine Kinase and DNA Polymerase Genes of Herpes Simplex Virus Type 1 Clones Passaged in the Presence of Acyclovir or Penciclovir

A total of 21 clones of acyclovir (ACV)-resistant (ACV(r)) herpes simplex virus type 1 (HSV-1) and 23 clones of penciclovir (PCV)-resistant (PCV(r)) HSV-1, emerging during serial passages in the presence of ACV or PCV, were isolated under conditions excluding contamination of resistant mutants in th...

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Autori principali: Suzutani, Tatsuo, Ishioka, Ken, De Clercq, Erik, Ishibashi, Kei, Kaneko, Hisatoshi, Kira, Toshihiko, Hashimoto, Koh-ichi, Ogasawara, Masahiro, Ohtani, Katsuki, Wakamiya, Nobutaka, Saijo, Masayuki
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2003
Soggetti:
Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC153316/
https://ncbi.nlm.nih.gov/pubmed/12709344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.5.1707-1713.2003
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