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Thymidine Kinase Mutations Conferring Acyclovir Resistance in Herpes Simplex Type 1 Recombinant Viruses

Contributions of thymidine kinase (TK) mutations to acyclovir (ACV) resistance were evaluated in herpes simplex virus type 1 recombinant viruses generated using a set of overlapping cosmids and plasmids. Alterations in both conserved and nonconserved regions of the TK gene were shown to confer high...

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Detalhes bibliográficos
Main Authors: Sergerie, Yan, Boivin, Guy
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1635219/
https://ncbi.nlm.nih.gov/pubmed/16982796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00889-06
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