Hydrogen–Deuterium Exchange of Lipoxygenase Uncovers a Relationship between Distal, Solvent Exposed Protein Motions and the Thermal Activation Barrier for Catalytic Proton-Coupled Electron Tunneling

[Image: see text] Defining specific pathways for efficient heat transfer from protein–solvent interfaces to their active sites represents one of the compelling and timely challenges in our quest for a physical description of the origins of enzyme catalysis. Enzymatic hydrogen tunneling reactions con...

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Udgivet i:ACS Cent Sci
Main Authors: Offenbacher, Adam R., Hu, Shenshen, Poss, Erin M., Carr, Cody A. M., Scouras, Alexander D., Prigozhin, Daniil M., Iavarone, Anthony T., Palla, Ali, Alber, Tom, Fraser, James S., Klinman, Judith P.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2017
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5492416/
https://ncbi.nlm.nih.gov/pubmed/28691068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.7b00142
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