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Comparative kinetic isotope effects on first- and second-order rate constants of soybean lipoxygenase variants uncover a substrate-binding network

Lipoxygenases are widespread enzymes found in virtually all eukaryotes, including fungi, and, more recently, in prokaryotes. These enzymes act on long-chain polyunsaturated fatty acid substrates (C18 to C20), raising questions regarding how the substrate threads its way from solvent to the active si...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Hu, Shenshen, Offenbacher, Adam R., Lu, Edbert D., Klinman, Judith P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6885649/
https://ncbi.nlm.nih.gov/pubmed/31624150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010826
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