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Hydrogen Tunneling in a Prokaryotic Lipoxygenase

[Image: see text] A bacterial lipoxygenase (LOX) shows a deuterium kinetic isotope effect (KIE) that is similar in magnitude and temperature dependence to the very large KIE of eukaryotic LOXs. This occurs despite the evolutionary distance, an ∼25% smaller catalytic domain, and an increase in E(a) o...

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Autors principals: Carr, Cody A. Marcus, Klinman, Judith P.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2014
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4004258/
https://ncbi.nlm.nih.gov/pubmed/24641705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi500070q
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