Chromosomal instability and lack of cyclin E regulation in hCdc4 mutant human breast cancer cells

INTRODUCTION: Cyclin E, a G(1 )cyclin essential for G(1)–S phase transition, is known to have a profound effect on tumorigenesis. Elevated levels of cyclin E have been associated with breast cancer, and chromosomal instability observed in breast cancer is suggested to be associated with constitutive...

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Bibliographic Details
Main Authors: Willmarth, Nicole E, Albertson, Donna G, Ethier, Stephen P
Format: Artigo
Language:Inglês
Published: BioMed Central 2004
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC549168/
https://ncbi.nlm.nih.gov/pubmed/15318934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr900
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