Overexpression of the Replication Licensing Regulators hCdt1 and hCdc6 Characterizes a Subset of Non-Small-Cell Lung Carcinomas : Synergistic Effect with Mutant p53 on Tumor Growth and Chromosomal Instability—Evidence of E2F-1 Transcriptional Control over hCdt1

Replication licensing ensures once per cell cycle replication and is essential for genome stability. Overexpression of two key licensing factors, Cdc6 and Cdt1, leads to overreplication and chromosomal instability (CIN) in lower eukaryotes and recently in human cell lines. In this report, we analyze...

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Bibliografski detalji
Glavni autori: Karakaidos, Panagiotis, Taraviras, Stavros, Vassiliou, Leandros V., Zacharatos, Panayotis, Kastrinakis, Nikolaos G., Kougiou, Dionysia, Kouloukoussa, Mirsini, Nishitani, Hideo, Papavassiliou, Athanasios G., Lygerou, Zoi, Gorgoulis, Vassilis G.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Investigative Pathology 2004
Teme:
Regular Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1618634/
https://ncbi.nlm.nih.gov/pubmed/15466399
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