Cdt1 associates dynamically with chromatin throughout G1 and recruits Geminin onto chromatin

To maintain genome integrity, eukaryotic cells initiate DNA replication once per cell cycle after assembling prereplicative complexes (preRCs) on chromatin at the end of mitosis and during G1. In S phase, preRCs are disassembled, precluding initiation of another round of replication. Cdt1 is a key m...

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Main Authors: Xouri, Georgia, Squire, Anthony, Dimaki, Maria, Geverts, Bart, Verveer, Peter J, Taraviras, Stavros, Nishitani, Hideo, Houtsmuller, Adriaan B, Bastiaens, Philippe I H, Lygerou, Zoi
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2007
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1817642/
https://ncbi.nlm.nih.gov/pubmed/17318181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601597
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