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Cdt1 Is Differentially Targeted for Degradation by Anticancer Chemotherapeutic Drugs
BACKGROUND: Maintenance of genome integrity is crucial for the propagation of the genetic information. Cdt1 is a major component of the pre-replicative complex, which controls once per cell cycle DNA replication. Upon DNA damage, Cdt1 is rapidly targeted for degradation. This targeting has been sugg...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3316709/ https://ncbi.nlm.nih.gov/pubmed/22479651 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034621 |
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