Cdt1 Is Differentially Targeted for Degradation by Anticancer Chemotherapeutic Drugs

BACKGROUND: Maintenance of genome integrity is crucial for the propagation of the genetic information. Cdt1 is a major component of the pre-replicative complex, which controls once per cell cycle DNA replication. Upon DNA damage, Cdt1 is rapidly targeted for degradation. This targeting has been sugg...

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Bibliographic Details
Main Authors: Stathopoulou, Athanasia, Roukos, Vassilis, Petropoulou, Chariklia, Kotsantis, Panagiotis, Karantzelis, Nickolas, Nishitani, Hideo, Lygerou, Zoi, Taraviras, Stavros
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3316709/
https://ncbi.nlm.nih.gov/pubmed/22479651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034621
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