Cdt1 is differentially targeted for degradation by anticancer chemotherapeutic drugs.

BACKGROUND: Maintenance of genome integrity is crucial for the propagation of the genetic information. Cdt1 is a major component of the pre-replicative complex, which controls once per cell cycle DNA replication. Upon DNA damage, Cdt1 is rapidly targeted for degradation. This targeting has been sugg...

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Main Authors: Athanasia Stathopoulou, Vassilis Roukos, Chariklia Petropoulou, Panagiotis Kotsantis, Nickolas Karantzelis, Hideo Nishitani, Zoi Lygerou, Stavros Taraviras
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2012-01-01
Colecção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC3316709?pdf=render
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