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A cycle of Zap70 kinase activation and release from the TCR amplifies and disperses antigenic stimuli
Cell-surface-receptor pathways amplify weak, rare and local stimuli to induce cellular responses. This task is accomplished despite signaling components that segregate into nanometer-scale membrane domains. Here we describe a ‘catch-and-release’ mechanism that amplified and dispersed stimuli by rele...
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| Veröffentlicht in: | Nat Immunol |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5490839/ https://ncbi.nlm.nih.gov/pubmed/27869819 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3631 |
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