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Nck Recruitment to the TCR Required for ZAP70 Activation during Thymic Development
The adaptor protein Nck is inducibly recruited through its SH3.1 domain to a proline-rich sequence (PRS) in CD3ε after TCR engagement. However, experiments with a knockin mutant bearing an 8-aa replacement of the PRS have indicated that Nck binding to the TCR is constitutive, and that it promotes th...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
AAI
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3549223/ https://ncbi.nlm.nih.gov/pubmed/23267019 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1202055 |
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