Nck Recruitment to the TCR Required for ZAP70 Activation during Thymic Development

The adaptor protein Nck is inducibly recruited through its SH3.1 domain to a proline-rich sequence (PRS) in CD3ε after TCR engagement. However, experiments with a knockin mutant bearing an 8-aa replacement of the PRS have indicated that Nck binding to the TCR is constitutive, and that it promotes th...

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Détails bibliographiques
Auteurs principaux: Borroto, Aldo, Arellano, Irene, Dopfer, Elaine P., Prouza, Marek, Suchànek, Miloslav, Fuentes, Manuel, Orfao, Alberto, Schamel, Wolfgang W., Alarcón, Balbino
Format: Artigo
Langue:Inglês
Publié: AAI 2013
Sujets:
Immune System Development
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549223/
https://ncbi.nlm.nih.gov/pubmed/23267019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1202055
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