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Negative regulation of TCR signaling by ubiquitination of Zap-70 Lys-217
The tyrosine kinase Zap-70 is a key regulator of T cell receptor (TCR) signaling downstream of antigen presentation, with coordinated regulation of Zap-70 kinase activity critical for proper T cell proliferation, differentiation, and effector function during an immune response. Zap-70 is cytosolic i...
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| Publié dans: | Mol Immunol |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4902731/ https://ncbi.nlm.nih.gov/pubmed/27032069 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2016.03.006 |
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