Pyruvate controls the checkpoint inhibitor PD-L1 and suppresses T cell immunity

Patients with coronary artery disease (CAD) are at high risk for reactivation of the varicella zoster virus (VZV) and development of herpes zoster (HZ). Here, we found that macrophages from patients with CAD actively suppress T cell activation and expansion, leading to defective VZV-specific T cell...

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Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: Watanabe, Ryu, Shirai, Tsuyoshi, Namkoong, Hong, Zhang, Hui, Berry, Gerald J., Wallis, Barbara B., Schaefgen, Benedikt, Harrison, David G., Tremmel, Jennifer A., Giacomini, John C., Goronzy, Jörg J., Weyand, Cornelia M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5490755/
https://ncbi.nlm.nih.gov/pubmed/28604383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI92167
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