Pyruvate controls the checkpoint inhibitor PD-L1 and suppresses T cell immunity

Patients with coronary artery disease (CAD) are at high risk for reactivation of the varicella zoster virus (VZV) and development of herpes zoster (HZ). Here, we found that macrophages from patients with CAD actively suppress T cell activation and expansion, leading to defective VZV-specific T cell...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Watanabe, Ryu, Shirai, Tsuyoshi, Namkoong, Hong, Zhang, Hui, Berry, Gerald J., Wallis, Barbara B., Schaefgen, Benedikt, Harrison, David G., Tremmel, Jennifer A., Giacomini, John C., Goronzy, Jörg J., Weyand, Cornelia M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5490755/
https://ncbi.nlm.nih.gov/pubmed/28604383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI92167
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