Immune checkpoint dysfunction in large and medium vessel vasculitis

Giant cell arteritis (GCA) is a granulomatous vasculitis of the aorta and its medium-sized branch vessels. CD4 T cells, macrophages, and dendritic cells (DCs) build granulomatous infiltrates that injure the vessel wall and elicit a maladaptive response to injury. Pathological consequences include fr...

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Vydáno v:Am J Physiol Heart Circ Physiol
Hlavní autoři: Watanabe, Ryu, Zhang, Hui, Berry, Gerald, Goronzy, Jörg J., Weyand, Cornelia M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2017
Témata:
Review
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5451585/
https://ncbi.nlm.nih.gov/pubmed/28314758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00024.2017
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