Immunoinhibitory checkpoint deficiency in medium and large vessel vasculitis

Giant cell arteritis (GCA) causes autoimmune inflammation of the aorta and its large branches, resulting in aortic arch syndrome, blindness, and stroke. CD4(+) T cells and macrophages form organized granulomatous lesions in the walls of affected arteries, destroy the tunica media, and induce ischemi...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Zhang, Hui, Watanabe, Ryu, Berry, Gerald J., Vaglio, Augusto, Liao, Yaping Joyce, Warrington, Kenneth J., Goronzy, Jörg J., Weyand, Cornelia M.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2017
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5307483/
https://ncbi.nlm.nih.gov/pubmed/28115719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1616848114
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky