Immunoinhibitory checkpoint deficiency in medium and large vessel vasculitis

Giant cell arteritis (GCA) causes autoimmune inflammation of the aorta and its large branches, resulting in aortic arch syndrome, blindness, and stroke. CD4(+) T cells and macrophages form organized granulomatous lesions in the walls of affected arteries, destroy the tunica media, and induce ischemi...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Zhang, Hui, Watanabe, Ryu, Berry, Gerald J., Vaglio, Augusto, Liao, Yaping Joyce, Warrington, Kenneth J., Goronzy, Jörg J., Weyand, Cornelia M.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2017
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PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5307483/
https://ncbi.nlm.nih.gov/pubmed/28115719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1616848114
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