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Inhibition of JAK-STAT signaling suppresses pathogenic immune responses in medium and large vessel vasculitis
BACKGROUND: Giant cell arteritis (GCA), a chronic autoimmune disease of the aorta and its large branches, is complicated by aneurysm formation, dissection, and arterial occlusions. Arterial wall dendritic cells (DC) attract CD4(+) T-cells and macrophages (Mo), to form prototypic granulomatous infilt...
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| Pubblicato in: | Circulation |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5930040/ https://ncbi.nlm.nih.gov/pubmed/29254929 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.117.030423 |
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