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Inhibition of JAK-STAT signaling suppresses pathogenic immune responses in medium and large vessel vasculitis

BACKGROUND: Giant cell arteritis (GCA), a chronic autoimmune disease of the aorta and its large branches, is complicated by aneurysm formation, dissection, and arterial occlusions. Arterial wall dendritic cells (DC) attract CD4(+) T-cells and macrophages (Mo), to form prototypic granulomatous infilt...

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Foilsithe in:Circulation
Main Authors: Zhang, Hui, Watanabe, Ryu, Berry, Gerald J., Tian, Lu, Goronzy, Jörg J., Weyand, Cornelia M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2017
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5930040/
https://ncbi.nlm.nih.gov/pubmed/29254929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.117.030423
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