Pyruvate controls the checkpoint inhibitor PD-L1 and suppresses T cell immunity

Patients with coronary artery disease (CAD) are at high risk for reactivation of the varicella zoster virus (VZV) and development of herpes zoster (HZ). Here, we found that macrophages from patients with CAD actively suppress T cell activation and expansion, leading to defective VZV-specific T cell...

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Detalles Bibliográficos
Publicado en:J Clin Invest
Main Authors: Watanabe, Ryu, Shirai, Tsuyoshi, Namkoong, Hong, Zhang, Hui, Berry, Gerald J., Wallis, Barbara B., Schaefgen, Benedikt, Harrison, David G., Tremmel, Jennifer A., Giacomini, John C., Goronzy, Jörg J., Weyand, Cornelia M.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2017
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5490755/
https://ncbi.nlm.nih.gov/pubmed/28604383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI92167
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