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Test and Evaluation of ff99IDPs Force Field for Intrinsically Disordered Proteins

Over 40% eukaryotic proteomic sequences have been predicted as intrinsically disordered proteins (IDPs) or intrinsically disordered regions (IDRs) and confirmed to be associated with many diseases. However, widely used force fields could not well reproduce the conformers of IDPs. A previously ff99ID...

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Vydáno v:J Chem Inf Model
Hlavní autoři: Ye, Wei, Ji, Dingjue, Wang, Wei, Luo, Ray, Chen, Hai-Feng
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5490450/
https://ncbi.nlm.nih.gov/pubmed/25919886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jcim.5b00043
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