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A Short Synthesis of (±)‐3‐Demethoxyerythratidinone by Ligand‐Controlled Selective Heck Cyclization of Equilibrating Enamines

A short, 5‐step total synthesis of (±)‐3‐demethoxyerythratidinone from a simple pyrrole derivative is described. Features include the formation of gram quantities of a key tricylic aziridine from a challenging photochemical cascade reaction through the use of flow photochemistry. The final step invo...

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Vydáno v:Angew Chem Int Ed Engl
Hlavní autoři: Blackham, Emma E., Booker‐Milburn, Kevin I.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5488232/
https://ncbi.nlm.nih.gov/pubmed/28470985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201701775
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