Magnetic Resonance Spectroscopy for Detection of 2-Hydroxyglutarate as a Biomarker for IDH Mutation in Gliomas

Mutations in the isocitrate dehydrogenase (IDH)1/2 genes are highly prevalent in gliomas and have been suggested to play an important role in the development and progression of the disease. Tumours harbouring these mutations exhibit a significant alteration in their metabolism resulting in the aberr...

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Bibliographic Details
Published in:Metabolites
Main Authors: Leather, Thomas, Jenkinson, Michael D., Das, Kumar, Poptani, Harish
Format: Artigo
Language:Inglês
Published: MDPI 2017
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5488000/
https://ncbi.nlm.nih.gov/pubmed/28629182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/metabo7020029
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