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Crystal Structure of the New Investigational Drug Candidate VT-1598 in Complex with Aspergillus fumigatus Sterol 14α-Demethylase Provides Insights into Its Broad-Spectrum Antifungal Activity

Within the past few decades, the incidence and complexity of human fungal infections have increased, and therefore, the need for safer and more efficient, broad-spectrum antifungal agents is high. In the study described here, we characterized the new tetrazole-based drug candidate VT-1598 as an inhi...

詳細記述

保存先:
書誌詳細
出版年:Antimicrob Agents Chemother
主要な著者: Hargrove, Tatiana Y., Garvey, Edward P., Hoekstra, William J., Yates, Christopher M., Wawrzak, Zdzislaw, Rachakonda, Girish, Villalta, Fernando, Lepesheva, Galina I.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487673/
https://ncbi.nlm.nih.gov/pubmed/28461309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00570-17
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