Structural Basis for Rational Design of Inhibitors Targeting Trypanosoma cruzi Sterol 14α-Demethylase: Two Regions of the Enzyme Molecule Potentiate Its Inhibition

[Image: see text] Chagas disease, which was once thought to be confined to endemic regions of Latin America, has now gone global, becoming a new worldwide challenge with no cure available. The disease is caused by the protozoan parasite Trypanosoma cruzi, which depends on the production of endogenou...

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Главные авторы: Friggeri, Laura, Hargrove, Tatiana Y., Rachakonda, Girish, Williams, Amanda D., Wawrzak, Zdzislaw, Di Santo, Roberto, De Vita, Daniela, Waterman, Michael R., Tortorella, Silvano, Villalta, Fernando, Lepesheva, Galina I.
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2014
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136671/
https://ncbi.nlm.nih.gov/pubmed/25033013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm500739f
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