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In Vitro and In Vivo Efficacy of an LpxC Inhibitor, CHIR-090, Alone or Combined with Colistin against Pseudomonas aeruginosa Biofilm

With the rapid spread of antimicrobial resistance in Gram-negative pathogens, biofilm-associated infections are increasingly harder to treat and combination therapy with colistin has become one of the most efficient therapeutic strategies. Our study aimed to evaluate the potential for the synergy of...

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Bibliografske podrobnosti
izdano v:Antimicrob Agents Chemother
Main Authors: Tan, Jun Hou, Vidaillac, Celine, Yam, Joey Kuok Hoong, Chua, Song Lin, Givskov, Michael, Yang, Liang
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487635/
https://ncbi.nlm.nih.gov/pubmed/28461320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02223-16
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