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Reduced sensory synaptic excitation impairs motor neuron function via Kv2.1 in spinal muscular atrophy

Behavioral deficits in neurodegenerative diseases are often attributed to the selective dysfunction of vulnerable neurons via cell-autonomous mechanisms. Although vulnerable neurons are embedded in neuronal circuits, the contribution of their synaptic partners to the disease process is largely unkno...

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Detalhes bibliográficos
Publicado no:Nat Neurosci
Main Authors: Fletcher, Emily V., Simon, Christian M., Pagiazitis, John G., Chalif, Joshua I., Vukojicic, Aleksandra, Drobac, Estelle, Wang, Xiaojian, Mentis, George Z.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487291/
https://ncbi.nlm.nih.gov/pubmed/28504671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.4561
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