Chronic Pharmacological Increase of Neuronal Activity Improves Sensory-Motor Dysfunction in Spinal Muscular Atrophy Mice

Dysfunction of neuronal circuits is an important determinant of neurodegenerative diseases. Synaptic dysfunction, death, and intrinsic activity of neurons are thought to contribute to the demise of normal behavior in the disease state. However, the interplay between these major pathogenic events dur...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Simon, Christian M., Blanco-Redondo, Beatriz, Buettner, Jannik M., Pagiazitis, John G., Fletcher, Emily V., Sime Longang, Josiane K., Mentis, George Z.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7810663/
https://ncbi.nlm.nih.gov/pubmed/33219005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2142-20.2020
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