Chronic Pharmacological Increase of Neuronal Activity Improves Sensory-Motor Dysfunction in Spinal Muscular Atrophy Mice

Dysfunction of neuronal circuits is an important determinant of neurodegenerative diseases. Synaptic dysfunction, death, and intrinsic activity of neurons are thought to contribute to the demise of normal behavior in the disease state. However, the interplay between these major pathogenic events dur...

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Détails bibliographiques
Publié dans:J Neurosci
Auteurs principaux: Simon, Christian M., Blanco-Redondo, Beatriz, Buettner, Jannik M., Pagiazitis, John G., Fletcher, Emily V., Sime Longang, Josiane K., Mentis, George Z.
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2021
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7810663/
https://ncbi.nlm.nih.gov/pubmed/33219005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2142-20.2020
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