Motor Neuron Rescue in Spinal Muscular Atrophy Mice Demonstrates That Sensory-Motor Defects Are a Consequence, Not a Cause, of Motor Neuron Dysfunction

The loss of motor neurons (MNs) is a hallmark of the neuromuscular disease spinal muscular atrophy (SMA); however, it is unclear whether this phenotype autonomously originates within the MN. To address this question, we developed an inducible mouse model of severe SMA that has perinatal lethality, d...

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Detalhes bibliográficos
Main Authors: Gogliotti, Rocky G., Quinlan, Katharina A., Barlow, Courtenay B., Heier, Christopher R., Heckman, C. J., DiDonato, Christine J.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3679185/
https://ncbi.nlm.nih.gov/pubmed/22423102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5775-11.2012
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