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Motor Neuron Rescue in Spinal Muscular Atrophy Mice Demonstrates That Sensory-Motor Defects Are a Consequence, Not a Cause, of Motor Neuron Dysfunction

The loss of motor neurons (MNs) is a hallmark of the neuromuscular disease spinal muscular atrophy (SMA); however, it is unclear whether this phenotype autonomously originates within the MN. To address this question, we developed an inducible mouse model of severe SMA that has perinatal lethality, d...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Gogliotti, Rocky G., Quinlan, Katharina A., Barlow, Courtenay B., Heier, Christopher R., Heckman, C. J., DiDonato, Christine J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Society for Neuroscience 2012
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3679185/
https://ncbi.nlm.nih.gov/pubmed/22423102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5775-11.2012
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