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Reduced sensory synaptic excitation impairs motor neuron function via Kv2.1 in spinal muscular atrophy

Behavioral deficits in neurodegenerative diseases are often attributed to the selective dysfunction of vulnerable neurons via cell-autonomous mechanisms. Although vulnerable neurons are embedded in neuronal circuits, the contribution of their synaptic partners to the disease process is largely unkno...

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Bibliografske podrobnosti
izdano v:Nat Neurosci
Main Authors: Fletcher, Emily V., Simon, Christian M., Pagiazitis, John G., Chalif, Joshua I., Vukojicic, Aleksandra, Drobac, Estelle, Wang, Xiaojian, Mentis, George Z.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487291/
https://ncbi.nlm.nih.gov/pubmed/28504671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.4561
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