Converging mechanisms of p53 activation drive motor neuron degeneration in spinal muscular atrophy

The hallmark of spinal muscular atrophy (SMA) – an inherited disease caused by ubiquitous deficiency in the SMN protein – is the selective degeneration of subsets of spinal motor neurons. Here we show that cell-autonomous activation of p53 occurs in vulnerable but not resistant motor neurons of SMA...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:Cell Rep
Glavni autori: Simon, Christian M., Dai, Ya, Van Alstyne, Meaghan, Koutsioumpa, Charalampia, Pagiazitis, John G., Chalif, Joshua I., Wang, Xiaojian, Rabinowitz, Joseph E., Henderson, Christopher E., Pellizzoni, Livio, Mentis, George Z.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5747328/
https://ncbi.nlm.nih.gov/pubmed/29281826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.12.003
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items