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Converging mechanisms of p53 activation drive motor neuron degeneration in spinal muscular atrophy
The hallmark of spinal muscular atrophy (SMA) – an inherited disease caused by ubiquitous deficiency in the SMN protein – is the selective degeneration of subsets of spinal motor neurons. Here we show that cell-autonomous activation of p53 occurs in vulnerable but not resistant motor neurons of SMA...
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| 發表在: | Cell Rep |
|---|---|
| Main Authors: | , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5747328/ https://ncbi.nlm.nih.gov/pubmed/29281826 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.12.003 |
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