Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR

G-protein-coupled receptors (GPCRs) have been shown to form dimers, but the relevance of this phenomenon in G-protein activation is not known. Among the large GPCR family, metabotropic glutamate (mGlu) receptors are constitutive dimers. Here we examined whether both heptahelical domains (HDs) are tu...

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Main Authors: Hlavackova, Veronika, Goudet, Cyril, Kniazeff, Julie, Zikova, Alice, Maurel, Damien, Vol, Claire, Trojanova, Johana, Prézeau, Laurent, Pin, Jean-Philippe, Blahos, Jaroslav
Format: Artigo
Language:Inglês
Published: 2005
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC548662/
https://ncbi.nlm.nih.gov/pubmed/15660124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600557
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