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Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR
G-protein-coupled receptors (GPCRs) have been shown to form dimers, but the relevance of this phenomenon in G-protein activation is not known. Among the large GPCR family, metabotropic glutamate (mGlu) receptors are constitutive dimers. Here we examined whether both heptahelical domains (HDs) are tu...
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| Publicado no: | EMBO J |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC548662/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15660124/ https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600557 |
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