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XIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPs
The X-linked inhibitor of apoptosis protein (XIAP) uses its second baculovirus IAP repeat domain (BIR2) to inhibit the apoptotic executioner caspase-3 and -7. Structural studies have demonstrated that it is not the BIR2 domain itself but a segment N-terminal to it that directly targets the activity...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2005
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC548652/ https://ncbi.nlm.nih.gov/pubmed/15650747 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600544 |
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