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XIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPs

The X-linked inhibitor of apoptosis protein (XIAP) uses its second baculovirus IAP repeat domain (BIR2) to inhibit the apoptotic executioner caspase-3 and -7. Structural studies have demonstrated that it is not the BIR2 domain itself but a segment N-terminal to it that directly targets the activity...

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Bibliografiset tiedot
Päätekijät: Scott, Fiona L, Denault, Jean-Bernard, Riedl, Stefan J, Shin, Hwain, Renatus, Martin, Salvesen, Guy S
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2005
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC548652/
https://ncbi.nlm.nih.gov/pubmed/15650747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600544
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