Mechanism of intramembrane proteolysis investigated with purified rhomboid proteases

Intramembrane proteases have the unusual property of cleaving peptide bonds within the lipid bilayer, an environment not obviously suited to a water-requiring hydrolysis reaction. These enzymes include site-2 protease, γ-secretase/presenilin, signal peptide peptidase and the rhomboids, and they have...

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Bibliografiske detaljer
Udgivet i:EMBO J
Main Authors: Lemberg, Marius K, Menendez, Javier, Misik, Angelika, Garcia, Maite, Koth, Christopher M, Freeman, Matthew
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2004
Fag:
Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC548647/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15616571/
https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600537
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