Arginase inhibition suppresses lung metastasis in the 4T1 breast cancer model independently of the immunomodulatory and anti-metastatic effects of VEGFR-2 blockade

Tumor angiogenesis promotes tumor growth and metastasis. Anti-angiogenic therapy in combination with chemotherapy is used for the treatment of metastatic cancers, including breast cancer but therapeutic benefits are limited. Mobilization and accumulation of myeloid-derived suppressor cells (MDSC) du...

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Detalles Bibliográficos
Publicado en:Oncoimmunology
Main Authors: Secondini, Chiara, Coquoz, Oriana, Spagnuolo, Lorenzo, Spinetti, Thibaud, Peyvandi, Sanam, Ciarloni, Laura, Botta, Francesca, Bourquin, Carole, Rüegg, Curzio
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2017
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Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5486183/
https://ncbi.nlm.nih.gov/pubmed/28680747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1316437
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