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Model‐based investigation of intracellular processes determining antibody Fc‐glycosylation under mild hypothermia
Despite the positive effects of mild hypothermic conditions on monoclonal antibody (mAb) productivity (q (mAb)) during mammalian cell culture, the impact of reduced culture temperature on mAb Fc‐glycosylation and the mechanism behind changes in the glycan composition are not fully established. The l...
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| Udgivet i: | Biotechnol Bioeng |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
John Wiley and Sons Inc.
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5485029/ https://ncbi.nlm.nih.gov/pubmed/27869292 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bit.26225 |
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