A Study of 11-[(3)H]-Tetrodotoxin Absorption, Distribution, Metabolism and Excretion (ADME) in Adult Sprague-Dawley Rats

Tetrodotoxin (TTX) is a powerful sodium channel blocker that in low doses can safely relieve severe pain. Studying the absorption, distribution, metabolism and excretion (ADME) of TTX is challenging given the extremely low lethal dose. We conducted radiolabeled ADME studies in Sprague-Dawley rats. A...

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Vydáno v:Mar Drugs
Hlavní autoři: Hong, Bihong, Chen, Hui, Han, Jiacai, Xie, Quanling, He, Jianlin, Bai, Kaikai, Dong, Yanming, Yi, Ruizao
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5484109/
https://ncbi.nlm.nih.gov/pubmed/28574462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md15060159
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